Ahmed M. Omer, Tamer M. Tamer, Mohamed S. Mohyeldin. HIGH-MOLECULAR WEIGHT OF BIOPOLYMER

DOI: http://dx.doi.org/10.15688/jvolsu10.2014.3.7

Ahmed M. Omer

Dr., Prof., Polymeric Materials Department,

Advanced Technologies and New Materials Research Institute,

City of Scientific Research and Technological Applications, Alexandria, Egypt;

Laboratory of Bioorganic Chemistry of Drugs,

Institute of Experimental Pharmacology and Toxicology,

Slovak Academy of Sciences, Bratislava, Slovakia

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Borg El-Arab City, 21934 Alexandria, Egypt

Tamer M. Tamer

Polymeric Materials Department, Advanced Technologies and New Materials Research Institute, City of Scientific Research and Technological Applications, Alexandria, Egypt

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Borg El-Arab City, 21934 Alexandria, Egypt

Mohamed S. Mohyeldin

Polymeric Materials Department, Advanced Technologies and New Materials Research Institute, City of Scientific Research and Technological Applications, Alexandria, Egypt

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Borg El-Arab City, 21934 Alexandria, Egypt

Abstract. Hyaluronan (HA) is a linear polysaccharide has a high-molecular weight, naturally occurring and found in all tissues and body fluids of higher animals. The excellent properties of HA such as biodegradability, biocompatibility, safety, excellent mucoadhesive capacity and high water retaining ability make it well-qualified for using in various bio-medical applications. In addition, HA is non-toxic, non-inflammatory and non-immunogenic. Because of all these advantages, HA has received much attention as a matrix for drug delivery system. This review will summarize our present knowledge about HA, its properties and development in some pharmaceutical applications.

Key words: hyaluronan, drug delivery system, hydrogel, antioxidant, high-molecular weight.

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