Erokhin V. N., Krementsova A. V., Semenov V. A., Burlakova E. B. THE EFFECT OF SYNTHETIC AND NATURAL ANTIOXIDANTS ON THE EMERGENCE AND DEVELOPMENT OF MALIGNANT TUMORS

DOI: http://dx.doi.org/10.15688/jvolsu10.2014.5.4 

Erokhin Valeriy Nikolaevich

Senior Researcher, Department of Kinetics of Chemical and Biological Processes, Institute of Biochemical Physics named after N.M. Emanuel of RAS

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Kosygina St., 4, 119334 Moscow, Russian Federation

Krementsova Anna Vladimirovna

Researcher, Department of Kinetics of Chemical and Biological Processes, Institute of Biochemical Physics named after N.M. Emanuel of RAS

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Kosygina St., 4, 119334 Moscow, Russian Federation

Semenov Vladimir Alekseevich

Researcher, Department of Kinetics of Chemical and Biological Processes, Institute of Biochemical Physics named after N.M. Emanuel of RAS

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Kosygina St., 4, 119334 Moscow, Russian Federation

Burlakova Elena Borisovna

Head of Department of Kinetics of Chemical and Biological Processes, Deputy Director of the Institute of Biochemical Physics named after N.M. Emanuel of RAS

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Kosygina St., 4, 119334 Moscow, Russian Federation

Abstract. The effect of different doses of synthetic antioxidant b-(4-hydroxy-3,5-ditertbutylphenyl), propionic acid (phenosan) and savory essential oil on the development of spontaneous leukemia was studied. The drug efficiency was determined from the survival curves, animal life spans, and the incidence of leukemia. Phenosan is characterized by clear antitumor activity in therapeutic (10-4 mol/kg) and ultra-low (10-14 mol/kg) doses. The dose of 10-14 mol/kg increases the life span. The savory essential oil in low doses mixed with drinking water (150 ng/ml) or food (2,5 mg/g) increased the average lifetime of mice by 20-35 %. The low doses of these drugs seem promising as preventive drugs.

Key words: antioxidants, low doses, propionic acid, spontaneous leukemia, preventive drugs.

 

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THE EFFECT OF SYNTHETIC AND NATURAL ANTIOXIDANTS ON THE EMERGENCE AND DEVELOPMENT OF MALIGNANT TUMORS by Erokhin V. N., Krementsova A. V., Semenov V. A., Burlakova E. B. is licensed under a Creative Commons Attribution 4.0 International License.

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