Kulish E.I., Shurshina A.S., Pearce Eli M. WAYS OF REGULATION OF RELEASE OF MEDICINAL SUBSTANCES FROM THE CHITOSAN FILMS
Kulish Elena Ivanovna
Doctor of Chemical Sciences, Associate Professor, Department of High-Molecular Compounds and Chemical Engineering, Bashkir State University
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Zaki Validi St., 32, 450076 Ufa, Russian Federation
Shurshina Anzhela Samatovna
Postgraduate Student, Department of High-Molecular Compounds and Chemical Engineering, Bashkir State University
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Zaki Validi St., 32, 450076 Ufa, Russian Federation
Pearce Eli M.
PhD, Professor, Brooklyn Branch of New York University
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Jay St., 300, Brooklyn, NY, USA
Abstract. The article studies the chitosan films obtained by applying acetic acid and two antibiotics of cephalosporin and aminoglycoside type. It investigates the possibility of their transport properties regulation in the sphere of medicines manufacture. This regulation can be carried out by films with thermal modification implying the heating of formed films at the temperature of about 120 °C and reaction with sodium dodecyl sulphate. The article shows that the antibiotics release from films will be determined by the amount of antibiotics connected with chitosan by hydrogen bonds, on the one hand, and by the state of the polymer matrix, on the other hand.
Key words: chitosan, modification, medicines manufacture, polymer matrix, films.
WAYS OF REGULATION OF RELEASE OF MEDICINAL SUBSTANCES FROM THE CHITOSAN FILMS by Kulish E.I., Shurshina A.S., Pearce Eli M. is licensed under a Creative Commons Attribution 4.0 International License.
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