STUDY OF DRUG COATING DURABILITY ON MEDICAL STENTS
Tatyana A. Ermakova
Candidate of Sciences (Chemistry), Associate Professor,
Department of Forensic Examination and Physical Materials Science,
Volgograd State University
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Prosp. Universitetsky, 100, 400062 Volgograd, Russian Federation
Dmitry V. Mordvinkin
Engineer, Laboratory of Analytical Chemistry and Corrosion,
JSC All-Russian Research, Design and Technological Institute
of Oil Refining and Petrochemical Equipment
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Prosp. im. V.I. Lenina, 98b, 400078 Volgograd, Russian Federation
Vladimir V. Akatiev
Senior Lecturer, Department of Forensic Examination and Physical Materials Science,
Volgograd State University
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Prosp. Universitetsky, 100, 400062 Volgograd, Russian Federation
Lilia V. Kamyshanova
Senior Lecturer,
Volgograd Institute of Management, Branch of the Russian Presidential Academy
of National Economy and Public Administration
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Gagarina St, 8, 400066 Volgograd, Russian Federation
Abstract. One of the effective methods of treatment of cardiovascular diseases is a minimally invasive method of surgical intervention called stenting. The structure of the stent in the form of a cylindrical metal mesh makes it possible to deliver the implant to the place of installation in a compressed state and, on site, to expand it to the size required by the vessel. To reduce the risk of restenosis, drug-coated stents are used in drug therapy. Despite this, to date, it has not been possible to completely prevent the development of restenosis. In this regard, the works on the development of drug coating composition and methods of their application on the metal surfaces of the medical stent are relevant. Studies on the development of a drug coating based on polyvinylpyrrolidone with the addition of acetylsalicylic acid have been carried out. This coating was applied to the surface of the medical stent analog by electrochemical deposition. The obtained drug coating was evaluated. Corrosion tests of the investigated samples with the applied coating were carried out by polarization resistance method. The dependence of corrosion resistance of the material on the concentration of acetylsalicylic acid in the composition of the drug coating was revealed.
Key words: corrosion, polyvinylpyrrolidone, acetylsalicylic acid, stenting, restenosis.
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