STUDY OF THE POSSIBILITY OF CREATING A DRUG COATING

FOR BILIARY STENTS BASED ON THE COPOLYMER

“POLYLACTIC ACID/POLYCAPROLACTONE” MODIFIED

WITH CARBON NANOTUBES AND DOXORUBICIN

Irina V. Zaporotskova

Doctor of Sciences (Physics and Mathematics), Professor,

Director of the Institute of Priority Technologies,

Volgograd State University

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Prosp. Universitetsky, 100, 400062 Volgograd, Russian Federation

Sergey G. Suchkov

Doctor of Sciences (Physics and Mathematics), Senior Researcher,

Director of the Scientific and Technological Center “Micro- and Nanoelectronics”,

Saratov National Research State University

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Astrakhanskaya St, 83, 410012 Saratov, Russian Federation

Sergey V. Boroznin

Candidate of Sciences (Physics and Mathematics), Associate Professor,

Head of the Department of Forensic Examination and Physical Materials Science,

Volgograd State University

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Prosp. Universitetsky, 100, 400062 Volgograd, Russian Federation

Daria A. Zvonareva

Assistant, Department of Forensic Examination and Physical Materials Science,

Volgograd State University

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Prosp. Universitetsky, 100, 400062 Volgograd, Russian Federation

Maria F. Chesheva

Assistant, Department of Forensic Examination and Physical Materials Science,

Volgograd State University

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Prosp. Universitetsky, 100, 400062 Volgograd, Russian Federation

Roman V. Shinkarev

Assistant, Department of Forensic Examination and Physical Materials Science,

Volgograd State University

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Prosp. Universitetsky, 100, 400062 Volgograd, Russian Federation

Abstract. Mechanical jaundice usually refers to a symptom complex that occurs when the outflow of bile through the bile ducts of the liver is disturbed. This disease is an indication for stenting. Unfortunately, over time, physicians have noted a number of disadvantages of endobiliary stenting, the main of which has been the manifestation of restenosis. Also, within the first few hours of completing the stenting procedure, there may be a risk of serious complications such as thrombosis and restenosis. To reduce the risks of such complications as well as to improve the future results of the operation, stents with special drug coatings have started to be used. To ensure local transportation, quality application of the drug substance on the surface of the biliary stent, and prolonged drug release, it is necessary to create a polymeric carrier complex. This article considers the possibility of creating an ultrathin drug coating for biliary stents. The article also presents theoretical calculations of the interaction of complexes of carrier polymers and the copolymer “polylactic acid/polycaprolactone” modified by carbon nanotubes. This coating is proposed to improve biocompatibility during endobiliary stenting.

Key words: stenting, ultrathin coating, polylactic acid, polycaprolactone, doxorubicin, carbon nanotubes.


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