INTERACTION MECHANISM AND TECHNOLOGY
FOR APPLICATION OF NEW ULTRA-THIN

DRUG COATING OF MEDICAL BILIARY STENTS

Daria A. Zvonareva

Assistant, Department of Forensic and Physical Materials Science,

Volgograd State University
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Prosp. Universitetsky, 100, 400062 Volgograd, Russian Federation

Evgenia E. An

Student, Departments of Forensic Science and Physical Materials Science,

Volgograd State University
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Prosp. Universitetsky, 100, 400062 Volgograd, Russian Federation

Maria F. Chesheva

Postgraduate Student, Department of Forensic and Physical Materials Science,

Volgograd State University
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Prosp. Universitetsky, 100, 400062 Volgograd, Russian Federation

Irina V. Zaporotskova

Doctor of Sciences (Physics and Mathematics), Professor,

Director of the Institute of Priority Technologies,

Volgograd State University
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Prosp. Universitetsky, 100, 400062 Volgograd, Russian Federation

Abstract. Several years ago, there were no effective methods for treating bile tract structures, 
but the situation changed significantly with the invention of the stent. The use of biliary stents 
for the treatment of mechanical jaundice made it easier to remove them from the body. However, 
it was not possible to stop the appearance of restenosis and thrombosis. To prevent such 
complications, drug coatings, which are a polymer matrix with drugs introduced into it, began to 
be applied to the stent surface. At present, despite the rather wide range of drug coatings, the 
search for new biodegradable carrier polymers that provide a high-quality and inexpensive coating
of biliary stents remains relevant. The paper considers the technology of creating a new ultra-thin 
drug coating for these stents based on polyvinylpyrrolidone with the addition of doxorubicin and 
carbon nanotubes. The invention proposes the use of carbon nanotubes based on their unique 
sorption properties. Steps of application of drug coating on stent surface and selection of optimal 
content of carbon nanotubes in coating composition are described. Theoretical studies of the 
interaction processes of drug coating components using the quantum-chemical method MNDO 
have been carried out. GAMESS, Gaussian, GaussView software packages were used for calculations.

Key words: drug coating, biliary stents, carbon nanotubes, polyvinylpyrrolidone, doxorubicin, adsorption.

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