Naumova G.A., Fomichev V.T., Borisanova Ya.A., Sinelnikova Yu.Yu. Use of Electrochemical Method of Water-Salt Solutions Micellization by Ions of Metals of 1st and 2nd Groups for Creation of Basis for Anticancer Agent
DOI: http://dx.doi.org/10.15688/jvolsu10.2016.1.7
Galina Alekseevna Naumova
Doctor of Technical Sciences, Professor,
Department of Bioengineering and Bioinformatics,
Volgograd State University
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Prosp. Universitetsky, 100, 400062 Volgograd, Russian Federation
Valeriy Tarasovich Fomichev
Doctor of Technical Sciences, Professor,
Head of Department of General and Applied Chemistry,
Volgograd State University of Architecture and Civil Engineering
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Akademicheskaya St., 1, 400074 Volgograd, Russian Federation
Yana Andreevna Borisanova
Postgraduate Student,
Volgograd State University
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Prosp. Universitetsky, 100, 400062 Volgograd, Russian Federation
Yuliya Yuryevna Sinelnikova
Student, Profile in Innovation Studies,
Volgograd State University
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Prosp. Universitetsky, 100, 400062 Volgograd, Russian Federation
Abstract. Today active work on search of new drugs with more sharp selectivity and various range of antineoplastic action is conducted. Modern researches of scientists in the field of creation of antineoplastic preparations have passed to a nanolevel. Works on creation of the antioncological preparations based on use of properties of nanodimensional particles of metals are conducted in many laboratories and the oncological centers of the world. For this purpose connections practically of all biogenous elements are offered: Na, Mg, K, Ca, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Mo.
It is well known that ions of many metals exert impact on a condition of immune system, being necessary metabolic components for all its links. Mechanisms of action of the existing onkopreparat on the basis of platinum metals, their pharmacokinetics, features of interaction with DNA currently are up to the end not studied.
Refer their toxicity and not selectivity of action to the main shortcomings. For the purpose of reduction of toxicity of this class of onkopreparat and a minimizirovaniye of risk of injury of healthy cells of an organism, and also decrease in quantity of side effects new dosage forms of preparations are developed.
In work options of use of antineoplastic preparations on the basis of solutions the mitsellirovannykh are considered by ions of metals. Works of the young scientists working in the leading Russian laboratories and options of support of their works are considered from the state. The effective and low-cost method of a mitsellirovaniye by ions of metals of water-salt solution and results of its analysis is offered. Results of the first experiences of impact of the solution received in the course of inorganic synthesis on living cells are studied. An attempt of expansion of research base for the purpose of promotion of this project is made.
Key words: micellization, nanostructured solution electrochemical method, metal ions, an anticancer drug.
Use of Electrochemical Method of Water-Salt Solutions Micellization by Ions of Metals of 1st and 2nd Groups for Creation of Basis for Anticancer Agent by Naumova G.A., Fomichev V.T., Borisanova Ya.A., Sinelnikova Yu.Yu. is licensed under a Creative Commons Attribution 4.0 International License.
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